A Clustal W alignment of protein homologs of Homo sapian CFH from Pan troglodytes, Mus musculus, Canis familiaris, and Bos taurus. Homo_sapia ---------- --------MR LLAKIICLML WAICVAEDCN ELPPRRNTEI Pan_troglo ---------- --------MR LLAKIICLML WAICVAEDCN ELPPRRNTEI Mus_muscul MVQHRFLLES VGPRKIQIMR LSARIIWLIL WTVCAAEDCK GPPPRENSEI Canis_fami ---------- --------MR FPGEIIWLIL WTVCVAEDCK EPPPRKETQV Bos_taurus ---------- --------MR FPAKIVWLVL WTVCVAEDCK EPPPRKETEI LTGSWSDQTY PEGTQAIYKC RPGYRSLGNV IMVCRKGEWV ALNPLRKCQK LIGSWSDQTY PEGTQAIYKC RPGYRSLGNI IMVCRKGEWV ALNPLRKCQK LSGSWSEQLY PEGTQATYKC RPGYRTLGTI VKVCKNGKWV ASNPSRICRK LSGAWLQQTY PEGTQATYKC RPGFRTLGAI IMECKNGEWV ALNPSRICQR LSGSWTEQTY QEGTQATYKC RPGYRTLGSI VMMCRGGKWV SLHPSRICRK RPCGHPGDTP FGTFTLTGGN VFEYGVKAVY TCNEGYQLLG EINYRECDTD RPCGHPGDTP FGTFTLTGGN VFEYGVKAVY TCNEGYQLLG EINYRECDTD KPCGHPGDTP FGSFRLAVGS QFEFGAKVVY TCDDGYQLLG EIDYRECGAD RPCGHPGDAS FGSFHLERGN KFEYGAKVVY TCNEGYQLIG RINFRECEPD KPCAHPGDTP FGSFHLAEGT QFEYGAKVVY TCDEGYQMVG EMNFRECDTN GWTNDIPICE VVKCLPVTAP ENGKIVSSAM EPDREYHFGQ AVRFVCNSGY GWTNDIPICE VVKCLPVTAP ENGKIVSSAM EPDREYRFGQ AVRFVCNSGY GWINDIPLCE VVKCLPVTEL ENGRIVSGAA ETDQEYYFGQ VVRFECNSGF GWTNDIPICE VVKCLPVTEP ENGRLASIPL ESDQEYTFGN VVRFECNSGF GWTNDIPICE VVKCLPVTEP ENGKIFSDAL EPDQEYTYGQ VVQFECNSGY KIEGDEEMHC SDDGFWSKEK PKCVEISCKS PDVINGSPIS QKIIYKENER KIEGDEEMHC SDDGFWSKEK PKCVEISCKS PDVINGSPIS QKIIYKESER KIEGHKEIHC SENGLWSNEK PRCVEILCTP PRVENGDGIN VKPVYKENER MLDGPSEIHC SANGIWSAEQ PRCVEISCQK PEIINGYLTF EKQTYKENER MLDGPKQIHC SAGGVWSAET PKCVEIFCKT PVILNGQAVL PKATYKANER FQYKCNMGYE YSERGDAVCT ESGWRPLPSC EEKSCDNPYI PNGDYSPLRI FQYKCNMGYE YSERGDAVCT ESGWRPLPSC EEKTCGNPYI PNGDYSPLRI YHYKCKHGYV PKERGDAVCT GSGWSSQPFC EEKRCSPPYI LNGIYTPHRI LHYKCHKGYE YSERGDTVCT KLGWIPSPSC KEALCPPPNI RNGDYTPKAT VQYRCAAGFE YGQRGDTICT KSGWTPAPTC IEITCDPPRI PNGVYRPELS KHRTGDEITY QCRNGFYPAT RGNTAKCTST GWIPAPRCTL KPCDYPDIKH KHRTGDEITY QCRNGFYPAT QGNTAKCTST GWIPAPRCTL KPCDYPNIKH IHRSDDEIRY ECNYGFYPVT GSTVSKCTPT GWIPVPRCTL KPCEFPQFKY KYRSGDAITY HCKSGFFSTI YGNKATCTDV GWVPLPRCSL KPCDFPEIKH KYRGQDKITY ECKKGFFPEI RGTDATCTRD GWVPVPRCAW KPCSYPVIKH GGLYHENMRR PYFPVAVGKY YSYYCDEHFE TPSGSYWDHI HCTQDGWSPA GGLYHENMRR PYFPVAVGKY YSYYCDERFE TASGSYWDYI HCTQDGWSPA GRLYYEESLR PNFPVSIGNK YSYKCDNGFS PPSGYSWDYL RCTAQGWEPE GSLDER--YR SYFPVAVGRS FYYHCDEDFV TPSERYWESI HCTPEGWIPE GRLYYS--YR GYFPARVNQQ FVYSCDHHFV PPSQRSWDHL TCTAEGWSPE VPCLRKCYFP YLENGYNQNH GRKFVQGKSI DVACHPGYAL PKAQTTVTCM VPCLRKCYFP YLENGYNQNY GRKFVQGKSI DVACHPGYAL PKEQTTVTCM VPCVRKCVFH YVENGDSAYW EKVYVQGQSL KVQCYNGYSL QNGQDTMTCT VPCRRRCTFH YLKNGQKPQR K-NYYQGQSV RVNCNNGHSL QNGHNIMTCT EPCLRQCIFN YLENGHTPYR EEKYLQGETV RVRCYEGYSL QNDQNTMTCT ENGWSPTPRC IRVKTCSKSS IDIENGFISE SQYTYALKEK AKYQCKLGYV ENGWSPTPRC VRVKTCSKSS IDIENGFISE SQYTYALKEK AKYQCKLGYV ENGWSPPPKC IRIKTCSASD IHIDNGFLSE SSSIYALNRE TSYRCKQGYV EDGWFPPPEC VPLKTCSTSQ IKIENGFFSE YELTYVLATV TQYQCKSGYL ESGWSPPPRC IRVKTCSKSN IRIENGFLSE STFTYPLNKQ TEYKCKPGYV TADGETSGSI TCGKDGWSAQ PTCIKSCDIP VFMNARTKND FTWFKLNDTL TADGETSGSI TCGKDGWSAQ PTCIKSCDIP VFMNARTKND FTWFKLNDTL TNTGEISGSI TCLQNGWSPQ PSCIKSCDMP VFENSITKNT RTWFKLNDKL TPDGKTSGTV KCLEKGWSPQ PICIKSCDMP VPENARIKSN ATWFGLNDNV TADGKTSGLI TCLKNGWSAQ PVCIKSCDRP VFEKARVKSD GTWFRLNDRL DYECHDGYES NTGSTTGSIV CGYNGWSDLP ICYERECELP KIDVHLVPDR DYECHDGYES NTGSTTGSIV CGYNGWSDLP ICYERECELP KIDVHLVPDR DYECLVGFEN EYKHTKGSIT CTYYGWSDTP SCYERECSVP TLDRKLVVSP DYECYDGFEG RQGR-TGSIV CGDDGWSHKP ACFEIECKIP KIDAQLLPIP DYECVDGYEN RDGRTTGSIV CGQDGWSDKA ACYERECSIP EMDPYLNAYP KKDQYKVGEV LKFSCKPGFT IVGPNSVQCY HFGLSPDLPI CK-EQVQSCG KKDQYKVGEV LKFSCKPGFT IVGPNSVQCY HFGLSPDLPI CK-EQVQSCG RKEKYRVGDL LEFSCHSG-H RVGPDSVQCY HFGWSPGFPT CK-GQVASCA KKDKYKVGDV LKFSCRPRFI RVGPESIQCY HFGWSPVFPI CK-EQTKHCA RKETYKVGDV LKFSCSQGRI MVGADSVQCY HFGWSPKLPT CKVKKVKSCA PPPELLNGNV KEKTKEEYGH SEVVEYYCNP RFLMKGPNKI QCVDGEWTTL PPPELLNGDV KEKTKEEYRH SEVVEYYCNP RFLMKGPNKI QCVDGEWTTL PPLEILNGEI NGAKKVEYSH GEVVKYDCKP RFLLKGPNKI QCVDGNWTTL APPHLLNGEV KETQKETYEH NDLVEYVCNT RFLMKGFNKI QCIDGEWTDL LPPELPNGKR KEIHKEEYAH NEVVEYACNP RFLMKGSHKI QCVDGEWTAL PVCIVEESTC GDIPELEHG- WAQLSSPPYY YGDSVEFNCS ESFTMIGHRS PVCIVEESTC GDIPELEHG- WAQLSSPPYY YGDSVEFNCS ESFTMIGHRS PVCIEEERTC GDIPELEHG- SAKCSVPPYH HGDSVEFICE ENFTMIGHGS PMCIEVESTC GDIPELDYGS VVESSNSPYH HGDSVEFSCK EEYTMVGPKS PVCIEEERTC GNIPDLDHG- DVKPSVPPYH HGDSVEFSCR EAFTMIGPRF ITCIHGVWTQ LPQCVAIDKL KKCKSSNLII LEEHLKNKKE FDHNSNIRYR ITCIHGVWTQ LPQCVAIDKL KKCKSSNLII LEEHLKNKKE FDHNSNIRYR VSCISGKWTQ LPKCVATDQL EKCRVLKSTG IEAIKPKLTE FTHNSTMDYK ITCISGMWTE PPQCIATDEL KKCT-YRLTK YEANPLDNII FDHNDNISYK ITCISGEWTQ PPQCIATDEL RKCKGSTLFP PEGRQAHKIE YDHNTNKSYQ CRGKEGWIHT VCINGRWDPE VNC-SMAQIQ LCPPPPQIPN SHNMTTTLNY CRGKEGWIHT VCINGRWDPE VNC-SMAQIQ LCPPPPQIPN SHNMTTTLNY CRDKQEYERS ICINGKWDPE PNC-TSKTS- -CPPPPQIPN TQVIETTVKY CRRTLKQKNS TCINGQWDPE LTCIEVEK-Q SCPPPPQIPN AQNVITTVNF CRGKSEHKHS ICINGEWDPK VDCNEEAKIQ LCPPPPQVPN ACDMTTTVNY RDGEKVSVLC QENYLIQEGE EITCKDGRWQ SIPLCVEKIP CSQPPQIEHG RDGEKVSVLC QENFLIQEGE EIACKDGRWQ SIPLCVEKIP CSQPPQIEHG LDGEKLSVLC QDNYLTQDSE EMVCKDGRWQ SLPRCIEKIP CSQPPTIEHG KDGEKVSVVC QDDYIIQDAE EIVCKDGRWQ SVPRCIEKIP CPQPSPIEHG QDGEKISILC KENYLIQDAE EIVCKDGRWQ SIPRCIEKIG CSQPPQIDHG TINSSRSSQE --------SY AHGTKLSYTC EGGFRISEEN ETTCYMGKWS TINSSRSSQE --------SY AHGTKLSYTC EGGFRLSEEN ETTCYMGKWS SINLPRSSEE RRDSIESSSH EHGTTFSYVC DDGFRIPEEN RITCYMGKWS TIKSSIFSEE IEETSKPKSY PHGSKLNYTC EDGFRVSEKD EITCQMGKWS TISSSSSAEE RREIHEQRLY AHGTKLSYTC EEGFEISENN VIICHMGKWS SPPQCEGLPC KSPP-EISHG VVAHMSDSYQ YGEEVTYKCF EGFGIDGPAI SPPQCEGLPC KSPP-EISHG VVAHMSDSYQ YGEEVTYKCF EGFGIDGPAI TPPRCVGLPC GPPP-SIPLG TVSLELESYQ HGEEVTYHCS TGFGIDGPAF SLPRCVGLPC APPAYMVTHG ILIQQSDSYQ YGEEVMYKCD DGFAIDGPAS SPPQCVGLPC GLPPYVQN-G VVSHKKDRYQ YGEEVTYDCD EGFGTDGPAS AKCLGEKWSH PPSCIKTDCL SLPSFENAIP MGEKKDVYKA GEQVTYTCAT AKCLGEKWSH PPSCIKTDCL SLPSFENAIP MGEKKDLYKA GEQVTYTCAT IICEGGKWSD PPKCIKTDCD VLPTVKNAII RGKSKKSYRT GEQVTFRCQS VKCLGGKWSN PPKCIKTDCF NLPSFGNAIP IGPKKVLYRS EEKVTYRCPT IRCLGGEWSR PQDCISTNCV NLPTFEDAVL TDREKDFYRS GEQVAFKCLS YYKMDGASNV TCINSRWTGR PTCRDTSCVN PPTVQNAYIV SRQMSKYPSG YYKMDGASNV TCINSRWTGR PTCRDTSCVN PPTVQNAYIV SRQMSKYPSG PYQMNGSDTV TCVNSRWIGQ PVCKDNSCVD PPHVPNATIV TRTKNKYLHG YYHMDGPNFV QCLNGQWIGS PVCKDMSCES PPKVKNAIVL N-ERSRYLPG YYQLDGSNTI QCIKSKWIGR PACRDVSCGN PPQVENAIIH N-QKSKYQSE ERVRYQCRSP YEMFGDEEVM CLNGNWTEPP QCKDSTGKCG PPPPIDNGDI ERVRYQCRSP YEMFGDEEVM CLNGNWTEPP QCKDSTGKCG PPPPIDNGDI DRVRYECNKP LELFGQVEVM CENGIWTEKP KCRDSTGKCG PPPPIDNGDI WSVHYECIKP FDLFGEAEVT CLNGTWTNPP QCGESKGKCG PPPPIDNGDI ERARYECIGN YDLFGEMEVV CLNGTWTEPP QCKDSQGKCG PPPPIDNGDI TSFPLSVYAP ASSVEYQCQN LYQLEGNKRI TCRNGQWSEP PKCLHPCVIS TSFPLSVYAP ASTVEYQCQN LYELEGNKRI TCRNGQWSEP PKCLHPCVIS TSLSLPVYEP LSSVEYQCQK YYLLKGKKTI TCRNGKWSEP PTCLHACVIP TSFPLSAYAP ESTVEYKCQS LYALQGNRIV RCRNGQWTKP PKCLDACVVS TSLLQSVYPP GMIVEYRCQA YYELRGNKNV VCRNGEWSQL PKCLEACVIS REIMENYNIA LRWTAKQKLY SRTGESVEFV CKRGYRLSSR SHTLRTTCWD REIMEKYNIA LRWKAKEKIY SRTGESVEFI CKNGYRLSPS SHALRTACWD ENIMESHNII LKWRHTEKIY SHSGEDIEFG CKYGYYKARD SPPFRTKCIN EDIMRRNNIR FRWSSETKLY SQTRDTVEFE CIPGYHSKTN NQVFRAVCHE EETMRKHHIQ LRWKHDKKIY SKTEDTIEFM CQHGYRQLTP KHTFRATCRE GKLEYPTCAK R GKLEYPTCVK R GTINYPTCV- - GKMTYPVCV- - GKVVYPRCG- -