This web page was produced as an assignment for Gen677 at UW-Madison Spring 2010.

Go terms


The following are the Go terms for CFH from the Gene Ontology website Amigo.

Process:
  • complement activation
  • complement activation (alternative pathway)
  • immune response
  • innate immune response
Component:
  • extracellular space
  • extracellular region

CFH and the Complement Pathway

Picture
Image taken from www.biocarta.com
CFH plays a crucial role in the regulation of the complement system.  It is the cofactor for complement factor I (CFI) of cleavage of C3b.  C3b is necessary to continue the cascade of the complement system response.  When C3b is cleaved by CFI and CFH, the complement system is down-regulated.  CFH also accelerates the decay of C3 Convertase.  C3 Convertase is necessary to cleave C3 into C3b and C3a to replenish the pool of C3b (1). 


References:
1. Jha, P., P. S. Bora, and N. S. Bora. 2007. The role of complement system in ocular diseases including uveitis and macular degeneration. Molecular Immunology. 3901-2908.


Picture
Amigo: http://amigo.geneontology.org/cgi-bin/amigo/search.cgi?session_id=3794amigo1269836852
Rebecca Bauer
 [email protected]
last updated 5/17/2010 
www.gen677.weebly.com